Updated: The company now says it has raised $20 million, led by Clay Mathile, CEO of CYMI technologies, and former CEO and owner of the Iams Company. The company has also appointed Peter Low, previously its COO, as its President and CEO. Low replaces Dalen Harrison, who remains on the board.

Original post: Interactive video company Ensequence continues to raise some big rounds: after a $40 million third round from an unidentified PE firm in 2007, it is now raising $22.5 million in a fourth round, and has raised about $14.5 million of it already from a single investor, according to an SEC document just filed. When it fully raises this round, its total funding since its founding in 2002 will touch the $100 million mark. The Portland, OR-based company has developed interactive tools for programmers, advertisers, and distributors, and has clients such as MTV Networks, NBC Universal, ESPN, Disney, MLB, DirecTV, BSkyB and others. Below is an implementation of its tools in “Deal or No Deal” show:

• ITV Software Firm Ensequence Raises $40 Million In Third Round
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